Karen Lyons, PhD


Research Interests

  • CCNs in Chondrogenesis

  • BMPs in Skeletal Growth and Osteogenic Differentiation

  • Regenerative Musculoskeletal Medicine Training Program


Doctoral Degree

  • PhD, Laboratory of Genetics, University of Wisconsin-Madison, 1989


  • BA with High Honors, Departmental Honors in Genetics, University of California, Berkeley, 1980

Post Graduate Training

  • Post-doctoral studies, Department of Cell and Developmental Biology, Harvard University, 1992-94

  • Post-doctoral studies, Department of Cell Biology, Vanderbilt University, 1989-92


  • American Association of Anatomists

  • American Society for Bone and Mineral Research

  • American Society for Matrix Biology

  • Council of Research, Academic Senate, UCLA

  • Executive Academic Action Committee (EAAC), Orthopaedic Surgery, UCLA

  • International CCN Society

  • Minority Access to Research Careers (MARC), UCLA

  • Orthopaedic Research Society

Awards and Recognition

  • Kappa Delta Ann Doner Vaughn Award, American Association of Orthopaedic Surgeons, 2008

  • Elected to Nomination Committee, Orthopaedic Research Society, 2008-2011

  • Elected to Program Committee, Orthopaedic Research Society, 2007-2008

  • Invited speaker, “Meet The Professor” Symposium, American Society for Bone and Mineral Research, 2007

  • Elected Chair, 2010 Cartilage Gordon Conference , 2007

  • Organizer, AAOS Symposium on Fracture Repair, American Association of Orthopaedic Surgeons, 2007

  • Elected to Council, American Society for Matrix Biology, 2006

  • Chair, Abstract Selection Committee, Annual Meeting of the American Society for Bone and Mineral Research, 2006, 2005

  • Marta Marx Eradication of Scleroderma Award (Scleroderma Foundation), 2004

  • AIMM (Advances in Mineral Metabolism) Investigator Award (American Society for Bone and Mineral Research), 2003

  • David Paul Kane Scholar (UCLA), 1998

  • UCLA Bridge Award, 1997

  • Richard F. Dwyer and Elaine W. Dwyer Award for Excellence (UCLA), 1996

  • Stein-Oppenheimer Award (UCLA), 1995

  • NIH Postdoctoral training grant, 1989-1990

  • NIH Predoctoral training grants, 1982-1984, 1986

  • Genetics Society of America Student Award, 1985

  • Alumni Scholarships, U.C. Berkeley, 1976, 1979

Research and Publications:

  1. Azen, E.A., K.M. Lyons, T. McGonigal, N.L. Barrett, L.S. Clements, N. Maeda, E.F. Vanin, D. Carlson, and O. Smithies (1984) Clones from the human gene complex coding for salivary proline-rich proteins. Proc. Natl. Acad Sci. (USA) 81: 5561-5565.

  2. Mamula, P.W., N.A. Heerman, C.G. Palmer, K.M. Lyons, and R.C. Karn (1985) Localization of the human salivary protein complex (SPC) to chromosome band 12p13.2. Cytogent. Cell Genet. 39: 279-284.

  3. Lyons, K.M., J.H. Stein and O. Smithies (1988) Length polymorphism in human proline-rich protein genes generated by unequal crossing over. Genetics 120: 267-278.

  4. Lyons, K.M., E.A. Azen, P.A. Goodman, and O. Smithies (1988) Many protein products from a few loci: assignment of human salivary proline-rich proteins to specific loci. Genetics 120: 255-265.

  5. Lyons, K.M., J.L. Graycar, A. Lee, S. Hashmi, P.B. Lindquist, E.Y. Chen, B.L.M. Hogan, and R. Derynck (1989) Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor ß gene superfamily. Proc. Natl. Acad. Sci. (USA) 86: 4554-4558.

  6. Lyons, K.M., R.W. Pelton and B.L.M. Hogan (1989) Patterns of expression of murine Vgr-1 and BMP-2 RNA suggest that transforming growth factor-ß-like genes co-ordinately regulate aspects of embryonic development. Genes and Devel. 3: 1657-1668.

  7. Lyons, K.M., R.W. Pelton, J.L. Graycar, R. Derynck, and B.L.M. Hogan (1989) Developmental expression of the murine vgr-1 gene: a new member of the TGF-ß multigene family. In Molecular Genetics of Early Drosophila and Mouse Development. Ed M.R. Capecchi, Cold Spring Harbor Laboratory Press, New York

  8. Lyons, K.M., R.W. Pelton, and B.L.M. Hogan (1990) Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A). Development 109: 833-844.

  9. Jones, C.M., K.M. Lyons, and B.L.M. Hogan (1990) Involvement of Bone Morphogenetic Protein 4 in morphogenesis and neurogenesis in the mouse. Development 111: 531-542.

  10. Dickinson, M.E., M.S. Kobrin, C.S. Silan, D.M. Kingsley, M.J. Justice, D.A. Miller, J.D. Ceci, L.F. Lock, A. Lee, A.M. Buchberg, L.D. Siracusa, K.M. Lyons, R. Derynck, B.L.M. Hogan, N.G. Copeland, and N.A. Jenkins (1990) Chromosomal localization of seven members of the murine TGF-ß superfamily suggests close linkage to several morphogenetic mutant loci. Genomics 6: 505-520.