John Adams, MD
Director, Orthopaedic Hospital Research Center
Research Interests
Sterol / Steroid Hormone Intracellular Trafficking, Action and Metabolism
Vitamin D and Human Immune Function
Bone
Stem Cells
Innovative Approaches for the Recruitment and Training of Clinical Scientists
Biomedical Informatics
Overview
John Adams, MD Overview
Dr. Adams is board certified in internal medicine and endocrinology, diabetes and metabolism. Dr. Adams has focused his research on sterol synthesis and metabolism, vitamin D and steroid hormone action, and osteoporosis. His research has been published in numerous peer-reviewed journals, including Nature, Science, Cell, Endocrinology, Molecular Endocrinology, Journal of Clinical Endocrinology and Metabolism, Journal of of Clinical Investigation, Annals of Internal Medicine and The New England Journal of Medicine. Dr. Adams serves as Associate Editor for the Journal of Bone and Mineral Research and on the editorial board for the Journal of Clinical Endocrinology and Metabolism.
Dr. Adams is an active member of several professional committees on the national scene. He currently serves on the Skeletal Biology Development and Disease, the Orthopedic Study Section for grant review at the National Institute for Arthritis and Musculoskeletal Diseases of the National Institutes of Health. Dr. Adams received his bachelor’s degree from the University of Kansas and his medical degree from the University of Kansas School of Medicine. He completed his fellowship in endocrinology and internal medicine at Massachusetts General Hospital, Harvard Medical School.
Education
MD, University of Kansas School of Medicine, Alpha Omega Alpha (third year), 1974
BA, Cum Laude, University of Kansas, 1971
Professional Certification
Diplomat, Leadership Strategies for Evolving Health Care Executives, Harvard School of Public Health, 2011
Diplomat, Endocrinology and Metabolism, American Board of Internal Medicine, 1985
Diplomat, American Board of Internal Medicine, 1979
Affiliations
Member, Orthopedic Research Society, 2007
Member, Association of American Physicians, 2002
Member, Western Association of Physicians, 1991
Member, American Society of Clinical Investigation, 1990
Member, American Association for the Advancement of Science, 1982
Member, American Society of Bone and Mineral Research, 1981
Member, Endocrine Society, 1980
Member, American Federation of Clinical Research, 1979
Member, American College of Physicians, 1978
Member, Alpha Omega Alpha, 1973
Awards and Recognition
Brasel Basic Science Award, Harbor-UCLA Medical Center, Torrance, CA, 2011
Broad Stem Cell Research Center Innovation Award, UCLA, 2010-2012
Internationally Elected Council Member, American Society for Bone and Mineral Research, 2009
American Society for Bone and Mineral Research Boy Frame Award for Clinical Excellence in Bone and Mineral Metabolism, 2005
Cedars-Sinai Research Institute Award for Creative, Multi-user Computing, 1994-1995
New Investigator (First) Award, National Institutes of Health, 1985
University of Southern California Faculty Innovation Award, 1983-1985
Young Investigator Award, American Society for Bone and Mineral Research, 1983
Clinical Associate Physician Award, National Institutes of Health General Clinic Research Center, 1982
National Research Service Award, National Institutes of Health, 1980 – 1982
University-Wide Research Award, University of Kansas, 1978
University of Kansas Resident Teaching Award in Medicine, 1978
Mustala Research Award in Clinical Pharmacology, University of Kansas School of Medicine, 1976
Haden Research Medal, University of Kansas School of Medicine 1975
Research and Publications:
Lomax GP, Adams JS, Jamieson C, Zaia J, Millan MT. Accelerating Stem Cell Treatments for Patients: The Value of Networks & Collaboration. Stem Cells Trans Med. June 26, 2015
James, AW, Shen J, Zhang X, Asatrian BS, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim HB, Wu BM, Lyons Km Adams JS, Ting K, Soo C. NELL-1 in the treatment of osteoporotic bone loss. Nat Commun. 2015 Jun 17;6:7362. PMCID: PMC4557288.
Wu L, Petrigliano FA, Ba K, Lee S, Bogdanov J, McAllister DR, Adams JS, Rosenthal AK, Van Handel B, Crooks GM, Lin Y, Evseenko D. Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. Osteoarthritis Cartilage, 2015 Feb;23(2):308-18. Epub 2014 Nov 20. PMCID: PMC4465392
Chun RF, Blatter E, Elliott S, Fitz-Gibbon S, Rieger S, Sagasti A, Adams JS, Hewison M. Cloning of a functional 25-hydroxyvitamin D-1α-hydroxylase in zebrafish (Danio rerio). Cell Biochem Funct. 2014 Dec;32(8):675-82. Epub 2014 Oct 7. PMCID: PMC4363119
Zhou R, Chun RF, Lisse TS, Garcia AJ, Xu J, Adams JS, Hewison M. Vitamin D and alternative splicing of RNA. J Steroid Biochem Mol Biol. 2015:148: 310-317. Epub 2014 Oct 16. PMCID: PMC4361308
Chun RF, Liu NQ, Lee T, Schall JI, Denburg MR, Rutstein RM, Adams JS, Zemel BS, Stallings VA, Hewison M. Vitamin D supplementation and antibacterial immune responses in adolescents and young adults with HIV/AIDS. J Steroid Biochem. 2015 Aug:148:290-297. Epub 2014 Aug 1. PMCID: PMC4312738
Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RMB, Vaidya P, Munoz MA, Schenk M, Swindell WR, Chun R, Zavala K, Hewison M, Adams JS, Horvath S, Pellegrini M, Bloom BR, Modlin RL. IL-32 is a molecular marker of a host defense network in human tuberculosis. Sci Transl Med. 6:250ra114, 2014. PMCID:PMC4175914.
Lisse TS, Kanagasabai V, Bajaj SP, Zhou R, Chun RF, Hewison, M, Adams JS. The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts. Bone Research. 2:1-11, 2014. PMCID: PMC4261231
Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol. 5:1-15, 2014. PMCID:PMC4000998
Yuan F-N F, Valiyaparambil J, Woods MC, Tran H, Pant R, Adams JS, Mallya, SM. Vitamin D signaling regulates oral keratinocyte proliferation in vitro and in vivo. Int J Oncol. 44:1625-1633, 2014. PMID:PMC24626468.