Edward Ebramzadeh, PhD


Director, The J. Vernon Luck, Sr, MD Orthopaedic Research Center

Research Interests:

  • Biomechanics

  • Implant Retrieval

  • Implant Performance

  • Wear and Tribology

  • Biomaterials

  • Fracture Fixation


Dr. Ebramzadeh is the Director of the J. Vernon Luck, Sr Orthopaedic Research Center located at the Orthopaedic Institute for Children in downtown LA. The Research Center includes five full-time research faculty focusing on Biomechanics, Implant Retrieval, Implant Performance, and Wear and Tribology of Biomaterials. Dr. Ebramzadeh has an extensive background in biomechanical design, development and evaluation of implants, including joint replacement prostheses, fracture fixation devices and related instrumentation.

He has also been involved in the evaluation of surgical procedures for deformity correction, such as pediatric spine deformities, and fracture fixation. Dr. Ebramzadeh is a member of the editorial board of several prominent orthopedic journals and is a member of the Hip Society.


Doctoral Degree

  • PhD in Biomaterials and Handicap Research, Göteborg University, Sweden, 1995

Masters Degree

  • MS in Mechanical Engineering, University of Southern California, 1981

Undergraduate Degree

  • BS in Mechanical Engineering, University of Southern California, 1980


  • Orthopaedic Research Society

  • The Hip Society

Awards and Recognition

  • The Hip Society 2011

  • The Hip Society John Charnley Award 2011

  • The Hip Society John Charnley Award 2006

  • Sumner L. Koch Award, American Society for Surgery of the Hand 1997

  • Graduate Orthopaedic Society Faculty Recognition Award, Department of Orthopaedics, University of Southern California 1996

Research and Publications:

  1. Park SH, Lu Z, Hastings RS, Campbell PA, & Ebramzadeh E: Five hundred fifty-five retrieved metal-on-metal hip replacements of a single design show a wide range of wear, surface features, and histopathologic reactions. Clinical Orthopaedics and Related Research 2018, 476(2), 261-278.

  2. Sangiorgio SN, Ebramzadeh E, Knutsen AR, Borkowski SL, Kalma JJ, Bengs BC: Fixation of non-cemented total hip arthroplasty femoral components in a simulated proximal bone defect model. The Journal of Arthroplasty 2013, 28(9), 1618-1624.

  3. Lu Z, & Ebramzadeh E. (2019) Origins of material loss in highly worn acetabular cups of metal-on-metal total hip replacements. Journal of Orthopaedic Research 37: 143-150.

  4. Ebramzadeh E, Campbell P, Tan TL, Nelson SD, Sangiorgio SN: Can wear explain the histological variation around metal-on-metal total hips? Clinical Orthopaedics and Related Research 2015, 473(2):487-494.

  5. Ebramzadeh E, Campbell PA, Takamura KM, Lu Z, Sangiorgio SN, Kalma JJ, De Smet KA, Amstutz HC: Failure modes of 433 metal-on-metal hip implants: How, why, and wear. The Orthopedic Clinics of North America 2011, 42(2):241-250, ix.

  6. Lee JL, Billi F, Sangiorgio SN, McGarry W, Krueger DJ, Miller PT, McKellop H, Ebramzadeh E: Wear of an experimental metal-on-metal artificial disc for the lumbar spine. Spine 2008, 33(6):597-606.

  7. Ebramzadeh E, Billi F, Sangiorgio SN, Mattes S, Schmoelz W, Dorr L: Simulation of fretting wear at orthopaedic implant interfaces. Journal of Biomechanical Engineering 2005, 127(3):357-363.

  8. Ebramzadeh E, Sangiorgio SN, Lattuada F, Kang JS, Chiesa R, McKellop HA, Dorr LD: Accuracy of measurement of polyethylene wear with use of radiographs of total hip replacements. The Journal of Bone and Joint Surgery American Volume 2003, 85-A(12):2378-2384.

  9. Borkowski SL, Sangiorgio SN, Bowen RE, Scaduto AA, B. H, Bauer K, Ebramzadeh E: Strength of thoracic spine under simulated direct vertebral rotation: A biomechanical study. Spine Deformity 2016, 4(2), 85-93.

  10. Knutsen AR, Borkowski SL, Ebramzadeh E, Flanagan CL, Hollister SJ, Sangiorgio SN: Static and dynamic fatigue behavior of topology designed and conventional 3D printed bioresorbable PCL cervical interbody fusion devices. Journal of the Mechanical Behavior of Biomedical Materials 2015, 49:332-342.

  11. Sangiorgio SN, Sheikh H, Borkowski SL, Khoo L, Warren CR, Ebramzadeh E: Comparison of three posterior dynamic stabilization devices. Spine 2011, 36(19):E1251-1258.

  12. Rajfer RA, Kilic A, Neviaser AS, Schulte LM, Hlaing SM, Landeros J, Ferrini MG, Ebramzadeh E, Park SH: Enhancement of fracture healing in the rat, modulated by compounds that stimulate inducible nitric oxide synthase: Acceleration of fracture healing via inducible nitric oxide synthase. Bone & Joint Research 2017, 6(2), 90-97.

  13. Ebramzadeh E, Knutsen AR, Sangiorgio SN, Brambila M, Harris TG: Biomechanical comparison of syndesmotic injury fixation methods using a cadaveric model. Foot & Ankle International 2013, 34(12):1710-1717.

  14. Silva M, Knutsen AR, Kalma JJ, Borkowski SL, Bernthal NM, Spencer HT, Sangiorgio SN, Ebramzadeh E: Biomechanical testing of pin configurations in supracondylar humeral fractures: the effect of medial column comminution. Journal of Orthopaedic Trauma 2013, 27(5):275-280.

  15. Thordarson DB, Motamed S, Hedman T, Ebramzadeh E, Bakshian S: The effect of fibular malreduction on contact pressures in an ankle fracture malunion model. The Journal of Bone and Joint Surgery American Volume 1997, 79(12):1809-1815.

  16. Sangiorgio SN, Ho NC, Morgan RD, Ebramzadeh E, Zionts LE: The objective measurement of brace-use adherence in the treatment of idiopathic clubfoot. The Journal of Bone and Joint Surgery 2016, 98(19), 1598-1605.

  17. Knutsen AR, Avoian T, Sangiorgio SN, Borkowski SL, Ebramzadeh E, Zionts LE: How do different anterior tibial tendon transfer techniques influence forefoot and hindfoot motion? Clinical Orthopaedics and Related Research 2014, 473(5), 1737-43.

  18. Ebramzadeh E, McKellop H, Dorey F, Sarmiento A: Challenging the validity of conclusions based on P-values alone: a critique of contemporary clinical research design and methods. Instructional Course Lectures 1994, 43:587-600.

See all Dr. Edward Ebramzadeh’s publications on PubMed